We present a joint analysis of optical emission-line and X-ray observations of the archetypical Galactic mixed-morphology supernova remnant (MMSNR) W28 (G6.4–0.1). MMSNRs comprise a class of sources whose shell-like radio morphology contrasts with a filled center in X-rays; the origin of these contrasting morphologies remains uncertain. Our CTIO images reveal enhanced [S ii] emission relative to Hα along the northern and eastern rims of W28. Hydroxyl (OH) masers are detected along these same rims, supporting prior studies suggesting that W28 is interacting with molecular clouds at these locations, as observed for several other MMSNRs. Our ROSAT HRI mosaic of W28 provides almost complete coverage of the supernova remnant (SNR). The X-ray and radio emission is generally anti-correlated, except for the luminous northeastern rim, which is prominent in both bands. Our Chandra observation sampled the X-ray-luminous central diffuse emission. Spectra extracted from the bright central peak and from nearby annular regions are best fit with two overionized recombining plasma models. We also find that while the X-ray emission from the central peak is dominated by swept-up material, that from the surrounding regions shows evidence for oxygen-rich ejecta, suggesting that W28 was produced by a massive progenitor. We also analyze the X-ray properties of two X-ray sources (CXOU J175857.55‑233400.3 and 3XMM J180058.5–232735) projected into the interior of W28 and conclude that neither is a neutron star associated with the SNR. The former is likely to be a foreground cataclysmic variable or a quiescent low-mass X-ray-binary, while the latter is likely to be a coronally active main-sequence star. Read more here.